[Prognostication of toxicity of a group of chemical compounds comprising anti-tuberculosis medicines by the quantitative structure-activity correlation method].

Balaban (J), Wiener (W), and Rouvray (R) topological indices as well as detour (Ip) and electropy (Ie) indices reflecting the structure of chemical substances were used to establish correlation between median lethal dose (LD50) of an anti-tuberculosis medicine and its molecular structure. Monocyclic compounds showed linear correlation between LD50 values and Balaban index (R = 0.93). Correlation between a maximum daily dose and electropy index was typical of the products having a more complicated structure. Results of this study open up prospects for the development of new anti-tuberculosis medicinal preparations characterized by reduced toxicity.

Laser diffraction for standardization of heterogeneous pharmaceutical preparations.

A new quantitative method for standardization of heterogeneous pharmaceutical preparations and their quality control during storage based on laser diffraction is proposed. A series of pharmaceutical dosage forms--suspensions, emulsions, tinctures, decoctions, cell preparations and others, are heterogeneous medicines. In some cases disperse phase can be formed during storage as a result of layering (L1/L2) or precipitation (S/L). Laser diffraction method proposed in this study can be used for standardization and quality control of medicines.

[Toxicity of non-steroid anti-inflammatory drugs]. / Nesteroidnye protivovospalitel'nye sredstva: k voprosu o toksichnosti.

Data are reported on toxicity of a majority of non-steroid anti-inflammatory drugs (NSAD), which are the most frequently used in clinical practice and whose chemical structures are different. The action mechanism and side effects of some NSAD, in particular, of diclofenac, ibuprofen and indometacin, are also in the focus of attention.